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Metal Gear Solid 3: In 1964, CIA agent Naked Snake is sent to Tselinoyarsk, USSR. Aided by Major Zero, Para-Medic, and his former mentor The Boss, Snake is tasked with rescuing defecting Soviet scientist Sokolov, who is secretly developing a nuclear-equipped tank, the Shagohod. Snake locates and escorts Sokolov, but encounters The Boss, who announces she is defecting to the USSR, and provides her new benefactor, Colonel Volgin, with two Davy Crockett nuclear shells. Sokolov is captured by the Cobra Unit, and Snake is thrown off a bridge by The Boss. Volgin steals the Shagohod and detonates one of the nuclear shells to cover up the theft, which is subsequently blamed on The Boss. The injured Snake is recovered via fulton extraction.

Metal Gear Solid - Peace Walker: Peace Walker begins on November 4, 1974. Big Boss is running his own mercenary unit in Colombia after leaving the United States following the formation of FOXHOUND at the end of Portable Ops. A mysterious paramilitary group equipped with a startling quantity of quality weapons, called the "Peace Sentinels", has been deployed in Costa Rica. Despite the Sentinels being equipped with firepower equivalent to that of a land army, the Costa Rican government cannot do anything about them because the country's constitution does not allow the creation of an official military. The Sentinels' presence threatens to endanger the balance of power between the East and West.